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Paxil should be taken once a day, either in the morning or evening, with or without food. Symptoms of depression can be triggered or worsened by life's difficulties. Paxil works by helping to restore the balance of serotonin - which helps reduce the symptoms of depression can be triggered or worsened by life's difficulties. As a result, people with panic disorder develop an intense fear of having another attack. Paxil works by helping to restore the balance of certain natural chemicals in the brain. This age group - where chronic depression can affect a large proportion of this population.